“如果某些狗屁炒作混入其中，只要能让我们朝着真正伟大的想法正确发力，那就值得——因为十个变革中有一个成功，也比十个逻辑推进步骤中七个成功要好。” — Jacob Becraft (@DrSynbio)

请收听我与 Jacob Becraft 的对话：

Tim 的创始人厨房——从头脑风暴到总统办公室，仅用两个月（嘉宾：Jake Becraft，Strand Therapeutics）(#868) — Tim Ferriss 作者博客

来源：https://tim.blog/2026/06/02/jake-becraft-strand-therapeutics/

“我希望世界明白，我们此刻正站在基因医学革命的前沿。”— Jake Becraft

Jake Becraft (https://x.com/DrSynbio) 是 Strand Therapeutics (https://www.strandtx.com/) 的 CEO 兼联合创始人，该公司正在构建生物技术领域最先进的可编程基因医学平台之一。在他的领导下，Strand 通过实现体内细胞选择性靶向和治疗载荷递送，重新定义了 RNA 药物的能力，开启了一类全新的精准基因疗法。他带领公司从创始愿景出发，历经平台开发，直至临床转化，使 Strand 站在下一代 RNA 疗法的前沿。

除了在 Strand 的职责外，Becraft 博士还是国家生物技术领域有影响力的声音。他在生物安全、创新战略以及加强美国在先进生物技术领域竞争力方面，为政策制定者、国防领导人和行业利益相关者提供咨询和建议。他在 MIT 接受合成生物学家的训练，活跃于科学、创业与政策的交叉领域，致力于构建可编程医学未来所需的公司和制度框架。

他拥有 MIT 生物工程与合成生物学博士学位。他是生物技术创新组织 (BIO) 和马萨诸塞州生物技术委员会 (MassBio) 的董事会成员。

敬请欣赏！

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Tim 的创始人厨房——从头脑风暴到总统办公室，仅用两个月（嘉宾：Jake Becraft，Strand Therapeutics）

其他播客平台

在 Apple Podcasts (https://podcasts.apple.com/us/podcast/868-tims-founder-kitchen-from-brainstorm-to-the/id863897795?i=1000770838211)、Spotify (https://open.spotify.com/episode/04EV7D2yhOJtKxuqyoC6TP?si=IoqB_IODQTiss2QuRD-Wtw)、Overcast (https://overcast.fm/+AAKebsHPS00)、Podcast Addict (https://podcastaddict.com/podcast/2031148#)、Pocket Casts (https://pca.st/timferriss)、Castbox (https://castbox.fm/channel/id1059468?country=us)、YouTube Music (https://music.youtube.com/playlist?list=PLuu6fDad2eJyWPm9dQfuorm2uuYHBZDCB)、Amazon Music (https://music.amazon.com/podcasts/9814f3cc-1dc5-4003-b816-44a8eb6bf666/the-tim-ferriss-show)、Audible (https://www.audible.com/podcast/The-Tim-Ferriss-Show/B08K58QX5W) 或你最喜欢的播客平台收听本期节目。

文字记录

• 本期节目 (https://tim.blog/2026/06/03/jake-becraft-strand-therapeutics-transcript/)
• 全部节目 (https://tim.blog/2018/09/20/all-transcripts-from-the-tim-ferriss-show/)

本期精选链接

• 联系 Jacob Becraft：

Twitter (https://twitter.com/drsynbio) | Strand Therapeutics (https://www.strandtx.com/)

书籍与推荐阅读

• Genentech: The Beginnings of Biotech (https://www.amazon.com/dp/022604551X/?tag=offsitoftimfe-20) by Sally Smith Hughes | Amazon
• The US Can’t Afford to Offshore Clinical Trials to China (https://archive.is/20260306133038/https://www.washingtonpost.com/opinions/2026/03/05/offshore-china-clinical-trials-biotechnology/) by Jacob Becraft | The Washington Post
• Strand Therapeutics Announces Initial First-in-Human Phase 1 Data for STX-001 at the 2025 ASCO Annual Meeting (https://www.biospace.com/press-releases/strand-therapeutics-announces-initial-first-in-human-phase-1-data-for-stx-001-in-patients-with-advanced-solid-tumors-at-the-2025-asco-annual-meeting) | BioSpace
• STX-001 ASCO Poster (https://cdn.prod.website-files.com/695c147ac34bdf172346e992/69635956db8f13b5987fce02_696142a228b115050b3ba912_STX-001-ASCO-2025-poster-FINAL.pdf) | Journal of Clinical Oncology
• The Nobel Prize: Checkpoint Inhibitors (https://www.ajmc.com/view/the-nobel-prize-checkpoint-inhibitors) | American Journal of Managed Care
• Scientists Create In Vivo CAR-T Therapy That Kills Cancer Cells Without Chemotherapy (https://innovativegenomics.org/news/in-vivo-car-t-cancer-fighting-immune-cells/) | Innovative Genomics Institute
• mRNA Startup Strand Therapeutics Lands $52M to “Program” New Cancer Therapies (https://medcitynews.com/2021/06/mrna-startup-strand-therapeutics-lands-52m-to-program-new-cancer-therapies/) | MedCity News
• The Abscopal Effect in the Era of Checkpoint Inhibitors (https://www.mdpi.com/1422-0067/22/13/7204) | National Library of Medicine
• Step 1: Collect Underpants, Step 2: ?, Step 3: Profit (https://knowyourmeme.com/memes/profit) | Know Your Meme
• Biologics: The Role of Delivery Systems in Improved Therapy (https://www.dovepress.com/biologics-the-role-of-delivery-systems-in-improved-therapy-peer-reviewed-fulltext-article-BTT) | Biologics
• How the Late Genzyme CEO Henri Termeer Created the Orphan Drug Industry (https://www.biocentury.com/article/286818/how-the-late-genzyme-ceo-henri-termeer-created-the-orphan-drug-industry) | BioCentury
• The Orphan Drug Act (ODA) (https://en.wikipedia.org/wiki/Orphan_Drug_Act_of_1983) | Wikipedia
• The Recent Large Reduction in Space Launch Cost (https://ntrs.nasa.gov/api/citations/20200001093/downloads/20200001093.pdf) | NASA Technical Reports Server
• FDA Rejects MDMA, Disappointing Drugmaker Lykos and the Psychedelics Industry (https://www.npr.org/sections/shots-health-news/2024/08/09/nx-s1-5068634/mdma-therapy-fda-decision-ptsd-psychedelic-treatment) | NPR
• Methylone: Distinct Pharmacological and Mechanistic Effects Compared with MDMA (https://transcendtherapeutics.com/methylone-distinct-pharmacological-and-mechanistic-effects-compared-with-mdma/) | Transcend Therapeutics
• Curing HIV — How Far Have We Come? (https://www.amfar.org/news/how-many-have-been-cured/) | amfAR
• How Has US Spending on Healthcare Changed over Time? (https://www.healthsystemtracker.org/chart-collection/u-s-spending-healthcare-changed-time/#Total%20national%20health%20expenditures,%201970-2024) | Peterson-KFF Health System Tracker
• Strand Tx CEO Jake Becraft Weighs in on FDA’s IND Reform, China (https://www.fiercebiotech.com/biotech/concerted-industry-government-effort-strand-ceo-jake-becraft-fda-ind-reform-and-china) | Fierce Biotech
• Testimony of Dr. Jacob Becraft Before the House Select Committee on the CCP (https://democrats-selectcommitteeontheccp.house.gov/sites/evo-subsites/democrats-selectcommitteeontheccp.house.gov/files/evo-media-document/becraft-testimony.pdf) | US House of Representatives
• Why More Biotechs Are Starting Trials in Australia (https://www.clinicalleader.com/doc/why-more-biotechs-are-starting-trials-in-australia-0001) | Clinical Leader
• SpaceX Vehicles: From Falcon 1 to Starship (https://www.spacex.com/) | SpaceX
• Strand’s Flywheel: Platforms for Tumor and T-Cell Delivery (https://www.kinnevik.com/insights/getting-to-know-strands-founder-and-ceo-jake-becraft/) | Kinnevik
• Domino’s Pizza Turnaround Case Study (https://dennisfoodservice.com/dominos-pizza-turnaround-case-study/) | Dennis Food Service
• Rides for Vaccinations (https://www.uber.com/us/en/impact/rides-for-vaccines/) | Uber Impact
• AlphaFold: Predicting Protein Structures with AI (https://deepmind.google/science/alphafold/) | Google DeepMind
• Elon Musk Went from Having 180 Million to Nearly Losing Everything (https://www.instagram.com/reels/DXjz90sEwEj/) | Leading Entrepreneurs
• All of Jeff Bezos’ Amazon Letters to Shareholders, 1997–2020 (https://quartr.com/insights/business-philosophy/collection-jeff-bezos-shareholder-letters) | Quartr
• AWS: Amazon’s “Side Hustle” That Reshaped the Cloud (https://www.aboutamazon.com/news/aws/aws-the-trillion-dollar-startup-side-hustle) | About Amazon
• How Josh Kushner Built Thrive Capital and Became a Billionaire Startup Investor (https://fortune.com/longform/josh-kushner-net-worth-thrive-capital-investments-openai-100-billion-valuation/) | Fortune
• COVID-19 Isn’t Political; Its Response Shouldn’t Be Politicized (https://globalhealthnow.org/2021-01/covid-19-isnt-political-its-response-shouldnt-be-politicized) | Johns Hopkins Bloomberg School of Public Health
• From Insulin to Humulin: The Story of the First Genetically Engineered Drug (https://geneticsunzipped.com/transcripts/2021/6/3/from-insulin-to-humulin-the-story-of-the-first-genetically-engineered-drug) | Genetics Unzipped
• Herceptin (Trastuzumab): The First HER2-Targeted Cancer Therapy (https://www.gene.com/medical-professionals/medicines/herceptin) | Genentech
• This Month in 1989: The Creation of Bristol-Myers Squibb (https://pmlive.com/pharma_news/this_month_in_1989_the_creation_of_bristol-myers_squibb_589307/) | PMLiVE
• “Short the Launch”: Biotech from Bust to Boom (https://www.baybridgebio.com/blog/biotech-bust-to-boom) | BayBridge Bio
• Arthur D. Levinson: From Genentech CEO to Apple Chairman (https://fi.edu/en/awards/laureates/arthur-d-levinson) | The Franklin Institute
• Apple, Its Control Over the iPhone, and The Internet (https://www.matthewball.co/all/applemetaverse) | Matthew Ball
• How Smartphones Changed Music and the Music Industry (https://www.hypebot.com/how-the-smartphones-changed-music-and-the-music-industry-kyle-bylin/) | Hypebot
• This May Be the Most Important Medical Story of the Decade (https://archive.is/20260409092311/https://www.nytimes.com/2026/04/09/opinion/genetic-editing-diseases-health-care.html) | The New York Times

电影

• Sophie’s Choice (https://www.amazon.com/dp/B0GR7F8FFQ/?tag=offsitoftimfe-20) | Prime Video

公司

• Strand Therapeutics (https://www.strandtx.com/)
• Amazon (https://www.amazon.com/)
• Andreessen Horowitz (https://a16z.com/)
• Anthropic (https://www.anthropic.com/)
• Apple (https://www.apple.com/)
• Amazon Web Services (AWS) (https://aws.amazon.com/)
• BlackBerry (https://www.blackberry.com/)
• Bristol Myers Squibb (BMS) (https://www.bms.com/)
• DeepMind (https://deepmind.google/)
• Domino’s Pizza (https://www.dominos.com/)
• Facebook (https://www.facebook.com/)
• Genentech (https://www.gene.com/)
• Genzyme (https://en.wikipedia.org/wiki/Genzyme)
• Google (https://www.google.com/)
• Holobiome (https://holobiome.org/)
• Merck (https://www.merck.com/)
• Meta (https://about.meta.com/)
• Microsoft (https://www.microsoft.com/)
• Moderna (https://www.modernatx.com/)
• Netflix (https://www.netflix.com/)
• The New York Times (https://www.nytimes.com/)
• OpenAI (https://openai.com/)
• PayPal (https://www.paypal.com/)
• PickFu (https://www.pickfu.com/)
• Playground Global (https://playground.global/)
• Polymarket (https://polymarket.com/)
• SpaceX (https://www.spacex.com/)
• Spotify (https://www.spotify.com/)
• Sweetgreen (https://www.sweetgreen.com/)
• Tesla (https://www.tesla.com/)
• Thrive Capital (https://thrivecap.com/)
• Uber (https://www.uber.com/)
• Uber Eats (https://www.ubereats.com/)
• The Washington Post (https://www.washingtonpost.com/)
• Zenno (https://www.zenno.space/)
• Zip2 (https://en.wikipedia.org/wiki/Zip2)

机构与组织

• American Society of Clinical Oncology (ASCO) (https://www.asco.org/)
• Advanced Research Projects Agency for Health (ARPA-H) (https://arpa-h.gov/)
• Center for Biologics Evaluation and Research (CBER) (https://www.fda.gov/about-fda/fda-organization/center-biologics-evaluation-and-research-cber)
• Congress (US) (https://www.congress.gov/)
• Defense Advanced Research Projects Agency (DARPA) (https://www.darpa.mil/)
• Department of Health (Abu Dhabi) (https://www.doh.gov.ae/en/)
• European Medicines Agency (EMA) (https://www.ema.europa.eu/en/homepage)
• Food and Drug Administration (FDA) (https://www.fda.gov/)
• Institutional Review Board (IRB) (https://en.wikipedia.org/wiki/Institutional_review_board)
• Medicaid (https://www.medicaid.gov/)
• Medicare (https://www.medicare.gov/)
• MIT (https://www.mit.edu/)
• MIT Media Lab (https://www.media.mit.edu/)
• MD Anderson Cancer Center (https://www.mdanderson.org/)
• Memorial Sloan Kettering Cancer Center (https://www.mskcc.org/)
• Nobel Prize (https://www.nobelprize.org/)
• Saisei Foundation (https://saiseifoundation.org/)
• The White House (https://en.wikipedia.org/wiki/White_House)

概念与疗法

• 80/20 Rule (Pareto Principle) (https://www.investopedia.com/terms/1/80-20-rule.asp)
• Abscopal Effect in Oncology (https://en.wikipedia.org/wiki/Abscopal_effect)
• American Society of Clinical Oncology (ASCO) Annual Meeting (https://www.asco.org/annual-meeting)
• Australia’s Clinical Trial Notification (CTN) Scheme (https://www.tga.gov.au/products/unapproved-therapeutic-goods/access-pathways/clinical-trials/clinical-trial-notification-ctn-scheme)
• CAR-T Cell Therapy: Cost and Manufacturing Challenges (https://www.technologyreview.com/2024/04/12/1091161/car-t-cancer-therapy-treatment-expense/)
• The Central Dogma of Molecular Biology (DNA -> RNA -> Protein) (https://www.genome.gov/genetics-glossary/Central-Dogma)
• Checkpoint Inhibitors and Cancer Immunotherapy (https://www.keytrudahcp.com/resources/mechanism-of-action/)
• Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) (https://crisprtx.com/)
• Cost of Goods Sold (COGS) (https://www.investopedia.com/terms/c/cogs.asp)
• Cutaneous vs. Visceral Metastases in Melanoma (https://pmc.ncbi.nlm.nih.gov/articles/PMC10572973/)
• FDA Investigational New Drug (IND) Application (https://www.fda.gov/drugs/types-applications/investigational-new-drug-ind-application)
• First Principles Thinking (https://fs.blog/first-principles/)
• In Vivo CAR-T Cell Therapy (https://www.nature.com/articles/s41573-025-01291-5)
• Institutional Review Boards (IRBs) and Clinical Trial Oversight (https://www.fda.gov/about-fda/cder-offices-and-divisions/institutional-review-boards-irbs-and-protection-human-subjects-clinical-trials)
• Kaplan-Meier Survival Curves (https://pmc.ncbi.nlm.nih.gov/articles/PMC3059453/)
• Keytruda (Pembrolizumab) by Merck (https://en.wikipedia.org/wiki/Pembrolizumab)
• Opdivo (Nivolumab) by Bristol Myers Squibb (https://en.wikipedia.org/wiki/Nivolumab)
• mRNA-Based Therapeutics (https://www.nature.com/articles/s41392-022-01007-w)
• mRNA Vaccines for COVID-19 (https://www.ijbs.com/v17p1446.htm)
• Strand’s STX-001: Phase 1 Trial in Solid Tumors (https://www.businesswire.com/news/home/20240530103588/en/Strand-Therapeutics-Announces-First-Patient-Dosed-with-Programmable-mRNA-Therapy-STX-001-in-Phase-1-Trial-for-Solid-Tumors)
• Turing Test (https://en.wikipedia.org/wiki/Turing_test)

人物

• Jeff Bezos (https://en.wikipedia.org/wiki/Jeff_Bezos)
• Jennifer Doudna (https://www.nobelprize.org/prizes/chemistry/2020/doudna/biographical/)
• Jamie Heywood (https://www.jamieheywood.com/)
• Jony Ive (https://en.wikipedia.org/wiki/Jony_Ive)
• Steve Jobs (https://en.wikipedia.org/wiki/Steve_Jobs)
• Steve Jurvetson (https://tim.blog/2023/12/13/steve-jurvetson/)
• Baby KJ (https://nucdf.org/news.html/article/2025/12/18/baby-kj-s-crispr-treatment-family-offers-update-researchers-share-next-steps)
• Josh Kush