FlowLet: Conditional 3D Brain MRI Synthesis using Wavelet Flow Matching
Summary
FlowLet is a conditional generative framework that synthesizes age-conditioned 3D brain MRIs using flow matching in an invertible wavelet domain, improving brain age prediction accuracy for underrepresented age groups with high efficiency.
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Paper page - FlowLet: Conditional 3D Brain MRI Synthesis using Wavelet Flow Matching
Source: https://huggingface.co/papers/2601.05212
Abstract
FlowLet is a conditional generative framework that synthesizes age-conditioned 3D MRIs using flow matching in an invertible 3D wavelet domain, improving brain age prediction performance for underrepresented age groups.
Brain Magnetic Resonance Imaging (MRI) plays a central role in studying neurological development, aging, and diseases. One key application isBrain Age Prediction(BAP), which estimates an individual’s biological brain age from MRI data. Effective BAP models require large, diverse, and age-balanced datasets, whereas existing 3D MRI datasets are demographically skewed, limiting fairness and generalizability. Acquiring new data is costly and ethically constrained, motivatinggenerative data augmentation. Current generative methods are often based onlatent diffusion models, which operate in learned low dimensional latent spaces to address the memory demands of volumetric MRI data. However, these methods are typically slow at inference, may introduce artifacts due to latent compression, and are rarely conditioned on age, thereby affecting the BAP performance. In this work, we propose FlowLet, a conditional generative framework that synthesizes age-conditioned 3D MRIs by leveragingflow matchingwithin aninvertible 3D wavelet domain, helping to avoid reconstruction artifacts and reducing computational demands. Experiments show that FlowLet generates high-fidelity volumes with few sampling steps. Training BAP models with data generated by FlowLet improves performance for underrepresented age groups, and region-based analysis confirms preservation of anatomical structures.
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