How should a high school student choose a major in the age of AI?

My younger brother is in high school and will be choosing a university major soon. He recently asked me what he should study, and it made me think about this more seriously. With AI developing so fast, choosing a major feels more complicated than before. It’s not just about what has a good salary now, but also what kind of work may still have value if more tasks become automated. One thing I keep thinking about is how to become harder to replace. For example, medicine still seems relatively safe in the short term. Not just because doctors know a lot, but because the work involves licensing, trust, responsibility, physical diagnosis, patient communication, and high-stakes decisions. But outside of medicine, I’m less sure. Should students choose majors connected to the physical world? Fields that require human trust and accountability? Something interdisciplinary, where AI becomes a tool rather than the whole job? Or is the major itself less important than building judgment, communication, problem framing, and real domain expertise? If a high school student today wants to avoid being easily replaced or optimized away by AI in the future, what should they consider when choosing a university major?