Claude Meets Blackwell Ultra: Anthropic’s Models Now Run on NVIDIA GB300 in Azure

<div id="bsf_rt_marker"></div><p><span style="font-weight: 400;">Anthropic’s Claude models in Microsoft Foundry — hosted on Microsoft Azure and running on NVIDIA GB300 Blackwell Ultra GPUs — are now generally available, giving Azure-native enterprises a powerful new way to build autonomous and domain-specific AI agents.</span></p> <p><span style="font-weight: 400;">As agentic AI continues to drive enterprise innovation and becomes more autonomous, organizations need access to computing power to build and deploy specialized agents to accelerate essential business tasks. And having great inference performance and efficiency reduces </span><span style="font-weight: 400;">total cost of ownership</span><span style="font-weight: 400;"> and drives positive company results.</span></p> <p><span style="font-weight: 400;">With Claude in Foundry running on </span><a target="_blank" href="https://www.nvidia.com/en-us/data-center/gb300-nvl72/"><span style="font-weight: 400;">NVIDIA GB300 NVL72</span></a><span style="font-weight: 400;"> systems with </span><a target="_blank" href="https://www.nvidia.com/en-us/networking/products/infiniband/quantum-x800/"><span style="font-weight: 400;">NVIDIA Quantum-X800 InfiniBand</span></a><span style="font-weight: 400;"> networking, enterprises can now build and run more powerful agentic systems, including autonomous and specialized sub-agents that can work across business domains to perform advanced tasks. </span></p> <h2><b>A Growing Partnership</b></h2> <p><span style="font-weight: 400;">NVIDIA is working with Anthropic to extend developer capabilities by integrating NVIDIA tools into the Anthropic stack. That integration enables enterprises to give Claude agents domain-specific abilities. Through NVIDIA verified </span><a target="_blank" href="https://github.com/nvidia/skills"><span style="font-weight: 400;">agent skills</span></a><span style="font-weight: 400;">, </span><span style="font-weight: 400;">enabled by access to NVIDIA accelerated computing, enterprises can embed AI agents deeply into their business and use them as the operating system for the organization.</span><span style="font-weight: 400;">   </span></p> <p><span style="font-weight: 400;">Enterprises can run Claude agents on Azure by using the </span><a target="_blank" href="https://developer.nvidia.com/blog/how-to-govern-autonomous-agents-in-enterprise-ai-factories"><span style="font-weight: 400;">NVIDIA Secure Agent Workspace Reference Design</span></a><span style="font-weight: 400;">. It provides a blueprint for running autonomous agents in a governed environment where identity, network access, credentials and runtime policy are controlled at the infrastructure level.</span></p> <p><span style="font-weight: 400;">Claude in Microsoft Foundry accelerated by NVIDIA GB300 GPUs on Azure builds on the strategic partnership </span><a target="_blank" href="https://blogs.microsoft.com/blog/2025/11/18/microsoft-nvidia-and-anthropic-announce-strategic-partnerships/"><span style="font-weight: 400;">Microsoft, NVIDIA and Anthropic announced in November</span></a><span style="font-weight: 400;"> to expand enterprise access to Claude and offer Anthropic models on NVIDIA accelerated computing. </span></p> <p><i><span style="font-weight: 400;">Get started by visiting </span></i><a target="_blank" href="https://ai.azure.com/catalog/publishers/anthropic"><i><span style="font-weight: 400;">Claude in Microsoft Foundry</span></i></a><i><span style="font-weight: 400;"> and learn more in </span></i><a target="_blank" href="https://aka.ms/ClaudeGAdocumentation"><i><span style="font-weight: 400;">Foundry documentation</span></i></a><i><span style="font-weight: 400;">.</span></i></p>