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Researchers used AI protein design tools to replace all structural elements outside the catalytic core of zinc proteases and cysteine proteases, designing novel proteases that can be customized to cleave specific proteins. They successfully demonstrated the ability to cut proteins associated with neurological disorders.
MIT研究人员开发了名为VibeGen的AI模型，该模型基于蛋白质的动态运动和力学特性进行设计，而非仅依赖静态结构。这种方法能够创造出具有特定振动和弯曲行为的蛋白质，推动了生成式AI在科学领域的发展。