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AgForce Enables Antigen-conditioned Generative Antibody Design

arXiv cs.LG · 2026-05-22 Cached

This paper identifies three failure modes in existing antibody design methods (antigen blindness, vocabulary collapse, convergence to marginal distribution) and proposes AgForce, a novel encoder-decoder architecture using graph neural networks and mixture density networks, achieving state-of-the-art binding quality and sequence recovery on the Chimera-Bench benchmark.

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