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Researchers used large genome models Evo 1 and Evo 2 to design new bacteriophage genomes, producing viruses with distinct features challenging to evolve naturally, raising questions about potential future design of vertebrate-targeting viruses.
US researchers used generative AI models Evo1 and Evo2 to design complete virus genomes for the first time, creating 16 novel bacteriophages that can kill E. coli. The breakthrough could enable new disease treatments but raises urgent safety and security concerns.
Arc Institute announces that their popular 2025 preprint on a framework for generating and evaluating AI-generated genomes is now published in Science. The work, from Brian Hie's lab, used Evo 1 and Evo 2 to design viable bacteriophage genomes.