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Researchers used AlphaFold AI to identify and redesign parts of gene-editing proteins (Cas9) responsible for off-target effects, significantly improving safety by reducing unintended edits.
Researchers used base editing, a precise genome editing technique, to study the role of the NANOG gene in human embryo development, revealing it is critical for forming pluripotent epiblast cells.
CRISPR technology has been developed to selectively target and destroy cancer cells, including those previously considered undruggable.
Scientists have achieved startling precision in editing genes within human embryos, marking a significant advancement in genetic engineering.
Arc Institute's PerturbSpace enables high-throughput single-cell profiling of transcriptome, location, CRISPR guides, clonal relationships, and surface proteins from many samples in one day, using standard single-cell sequencing.
This paper introduces Shesha, a geometric stability metric that quantifies directional coherence of single-cell CRISPR perturbation responses using mean cosine similarity, revealing regulatory architecture and predicting cellular stress across 2,200+ perturbations in five CRISPR datasets.