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A Phase 1 trial reports what may be the first successful rejuvenation of human eye cells, using three Yamanaka factors delivered as proteins to reprogram damaged retinal ganglion cells in glaucoma patients, based on David Sinclair's epigenetic reprogramming theory.
A six-month contest called Younger, founded by neuroscientist Christin Glorioso of NeuroAge Therapeutics, pits around 500 participants against each other to reverse their biological age as measured by a variety of aging clocks, aiming to build the world's most comprehensive biological age dataset.
Two new papers, one in Nature by Vadim Gladyshev's Harvard team and one in Cell by Juan Carlos Izpisua Belmonte's Altos Labs group, propose a new 'loss of cell identity' model of aging alongside the classic wear-and-tear model, highlighting epigenetic drift and mesenchymal drift as potential targets for anti-aging interventions.
A mouse study finds that early-life stress alters DNA packaging in brain cells, leaving a molecular scar that increases vulnerability to stress-related mental illnesses later in life.
The Hsu and Konermann labs at Arc Institute developed COMBINE, the first platform for systematically testing combinatorial interactions of epigenetic readers, writers, and erasers, screening over 50,000 effector pairs.