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Researchers at Stanford and the Arc Institute used AI models Evo 1 and Evo 2 to design hundreds of novel bacteriophage genomes, 16 of which produced fully functional viruses capable of infecting E. coli. The breakthrough opens new avenues for combating antibiotic resistance but raises biosecurity concerns.
Arc Institute announces that their popular 2025 preprint on a framework for generating and evaluating AI-generated genomes is now published in Science. The work, from Brian Hie's lab, used Evo 1 and Evo 2 to design viable bacteriophage genomes.