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This position paper argues that genomic model interpretability research must move beyond anecdotal evaluation, proposing a tiered framework for rigorous assessment of consistency, faithfulness, and biological validity, demonstrated through a benchmarking study on transcription factor binding.
Huggingface has open-sourced genomic foundational models, including Carbon, a DNA model that is 275x faster than the next best model and can process the entire human genome on a single GPU in under 2 days.