Nature 研究论文：无序蛋白的理性设计用于序列–功能研究

https://t.co/BRWg6DS0Er

无序蛋白的理性设计用于序列–功能研究

来源：https://www.nature.com/articles/s41586-026-10849-1?utm_source=x&utm_medium=social&utm_campaign=nature&linkId=63004835&error=cookies_not_supported&code=6960ef02-92f3-4072-a214-e565079b6853

数据可用性

本文用于图表和分析的数据与分析脚本可在 GitHub 获取（https://github.com/sukeniklab/GOOSE_2026 和 https://github.com/holehouse-lab/supportingdata/tree/master/2026/GOOSE_2026）。原始测序数据已存入 Zenodo82（https://www.nature.com/articles/s41586-026-10849-1#ref-CR82）（https://zenodo.org/records/18774462）。

代码可用性

GOOSE 完全开源，可在 GitHub 获取（https://github.com/idptools/goose/）。GOOSE 的使用文档可在线获取（https://goose.readthedocs.io/en/latest/）。GOOSE 的部分功能可通过两个 Colab Notebook 使用。用于序列生成和变异设计，请使用以下 notebook：https://colab.research.google.com/drive/1U9B-TfoNEZbbjhPUG5lrMPS0JL0nDB3o?usp=sharing。用于创建具有特定同型/异型 IDR–IDR 相互作用的序列，请使用以下 notebook：https://colab.research.google.com/drive/1aJajo1IK66ApFSMwCCBumCZixlfshw7A?usp=sharing。

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