Paper page - BioInsight: Multi-Agent Orchestration for Interactive Biomedical Knowledge Discovery

Source: https://huggingface.co/papers/2606.20997 Published on Jun 19

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Submitted byhttps://huggingface.co/Joysw909

Wangon Jul 2

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Abstract

BioInsight is a multi-agent system that transforms static biomedical reports into interactive, evidence-centered interfaces by organizing disease-specific evidence through structured artifacts and deterministic citation normalization.

Biomedical researchers increasingly use AI-generated analyses and reports to interpret protein-level signals, but static outputs are often insufficient for research decision-making, where users need to inspect evidence, assess uncertainty, compare mechanisms, and refine hypotheses. We present BioInsight, amulti-agent systemthat moves from static biomedical report generation to interactive evidence-centered interactive interface generation. Given a disease name, aprotein association table, and optional cohort metadata, BioInsight organizesdisease-specific evidencethroughtyped intermediate artifacts, includingranked pathways,literature evidence packets,protein-level reasoningnotes,citation-grounded reports,dashboard schemas, and renderedinteractive interfaces. The system decomposesevidence retrievalfrommechanistic reasoning, normalizes citations throughdeterministic components, and converts the same structured evidence used in the report into an interactive interface. We evaluate BioInsight on standardizedbiomedical QA, challengingprotein-function reasoning, andend-to-end biomedical evidence synthesis. Results show that BioInsight achieves best, and suggest that biomedical AI systems should move beyond text-only and static reports toward provenance-preserving, interactive evidence artifacts.

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