A Multiterminal Neuromorphic Biodevice Based on Biocompatible Quaternized Chitosan by Biomimicking Synaptic Integration and the Visual Nervous Processor System
A fully biocompatible multiterminal neuromorphic biodevice using quaternized chitosan is developed, operating at ultralow voltages and simulating visual nervous system processing.
# A Multiterminal Neuromorphic Biodevice Based on Biocompatible Quaternized Chitosan by Biomimicking Synaptic Integration and the Visual Nervous Processor System - PubMed
Source: [https://pubmed.ncbi.nlm.nih.gov/41782092/](https://pubmed.ncbi.nlm.nih.gov/41782092/)
\.2026 Mar 18;18\(10\):15387\-15397\.
doi: 10\.1021/acsami\.5c23804\.Epub 2026 Mar 4\.
Affiliations
- PMID:**41782092**
- DOI:[10\.1021/acsami\.5c23804](https://doi.org/10.1021/acsami.5c23804)
## A Multiterminal Neuromorphic Biodevice Based on Biocompatible Quaternized Chitosan by Biomimicking Synaptic Integration and the Visual Nervous Processor System
Xinqing Duanet al\.ACS Appl Mater Interfaces\.2026\.
## Abstract
The growing computational bottleneck of von Neumann systems underscores the urgent need for a brain\-inspired, energy\-efficient approach\. In response, a fully biocompatible multiterminal neuromorphic biodevice was developed using an acellular dermal matrix \(ADM\) as a biocompatible substrate, polylactic acid \(PLA\) as an insulator, quaternized chitosan \(QCS\) as a functional layer, and Au metal as electrodes while eliminating biological rejection risks\. Operating at ultralow voltages \(≤5 mV\), the biodevice reproduces complex neurodynamic spatial integration processes, surpassing conventional two\-terminal designs and enabling the simulation of the visual nervous processor system in the context of light adaptation\. Different visual receptive fields were also studied\. This work provides a feasible strategy for high\-performance biohybrid computing systems with minimal power consumption and further functional biomimicry\.
**Keywords:**acellular dermal matrix; biocompatible; neuromorphic biodevice; quaternized chitosan; synaptic integration\.
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- ### Full Text Sources - [American Chemical Society](https://doi.org/10.1021/acsami.5c23804)
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