@arcinstitute: Cells control gene expression through combinatorial interactions between readers, writers, and erasers of chromatin mar…
Summary
The Hsu and Konermann labs at Arc Institute developed COMBINE, the first platform for systematically testing combinatorial interactions of epigenetic readers, writers, and erasers, screening over 50,000 effector pairs.
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Cells control gene expression through combinatorial interactions between readers, writers, and erasers of chromatin marks, but most epigenetic editing tools rely on a single effector in isolation.
The @pdhsu & @SKonermann labs developed COMBINE: the first platform to systematically test those combinations at scale, screening 50,000+ effector pairs.
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