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The author argues that AI intelligence is not the main bottleneck for real-world progress, especially in medicine, where regulation and clinical trials remain the limiting factors despite AI hype.
This paper presents an LLM pipeline that converts clinical interview audio into transcripts, maps them to the ten MADRS depression items, estimates severity, and flags problematic ratings. Evaluation on real clinical interviews shows a strong correlation of 0.867 with expert ratings, offering interpretable support for depression assessment in clinical trials.
This paper introduces a benchmark framework to evaluate the faithfulness of LLM-generated clinical trial summaries for different stakeholder audiences, tests GPT-4o, Claude Sonnet 4.6, and Gemini 2.5 Flash on 1,800 summaries, and proposes a knowledge-graph-augmented retrieval system that improves faithfulness scores.
Neuralink announces first successful through-dura electrode implantation in clinical trials, improving safety and ease of brain interfacing.
Brain-computer interface trials are expanding rapidly, with a growing number of volunteers like Casey Harrell using implants to communicate and regain independence, marking a new phase in neurotechnology.
A study from King's College London reveals that hospitals and universities are conducting late-stage clinical trials for repurposing generic drugs at less than 10% of pharmaceutical companies' costs, offering affordable treatments for conditions like blindness, cancer prevention, and Covid.
Big progress against two of the most deadly cancers reported from randomized trials, as highlighted by Eric Topol during the ASCO conference.
This paper analyzes temporal and geographical trends in AI terminology in clinical trials from clinicaltrials.gov, using a hybrid human-AI approach with GPT-5.5. It finds increasing AI-related trials, with China and the US leading, and discusses the viability of hybrid screening for human-AI interaction classification.
AI is transforming U.S. pharmaceutical R&D by accelerating drug discovery, preclinical testing, clinical trials, and regulatory review, with early evidence suggesting it could cut development times by roughly half and reduce costs.
Paperclip adds over 220K FDA regulatory documents and 1M clinical trials from multiple registries, enabling AI agents to search and reason over clinical and regulatory data without web search. This update allows users to query FDA documents, ClinicalTrials.gov, and international registries via a unified filesystem interface.
After a car accident left her paralyzed, Audrey became the first female participant in Neuralink's clinical trials and now uses their brain-computer interface to create art with her mind.
The FDA launches a pilot program using Causal AI to shorten clinical trial timelines for drugs and medical devices, potentially reducing trial duration by 20-40% and speeding regulatory approval.
Beacon Biosignals is using a lightweight EEG headband and machine learning to map brain activity during sleep, aiming to create a foundation model for brain health and accelerate clinical trials for neurological disorders.
Researchers from Banting Health AI present an AI system using generative LLMs with Retrieval-Augmented Generation (RAG) for automated clinical trial protocol information extraction, achieving 89% accuracy compared to 62.6% for standalone LLMs, with AI-assisted workflows completing tasks 40% faster and reducing cognitive demand.
Paradigm leverages GPT-4's natural language understanding to dramatically improve patient screening for clinical trials, enabling evaluation of hundreds of patients per minute compared to manual review of ~50 per day, reducing clinician burden and improving patient access to treatments.