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A new preprint from the Arc Institute introduces PerturbSpace, a method for spatially resolved, multimodal whole-transcriptome CRISPR screens compatible with standard single-cell workflows.
This paper formalizes transcriptome-based drug design (TBDD) as a generative inverse problem and proposes CURE, a multi-resolution transcriptome-guided diffusion framework that generates drug molecules conditioned on desired transcriptomic state transitions.