@SylvainGariel: Took me a while to figure out what all the ESMFold2 rage was about. At first, the benchmarking data didn't look super r…

X AI KOLs Following Models
proteins ai-model open-source biology antibodies esmfold2 protein-structure

Summary

ESMFold2 is an open-source AI model for protein structure prediction that achieves state-of-the-art performance on protein interactions and antibodies, with a massive structure database (ESM Atlas).

Took me a while to figure out what all the ESMFold2 rage was about. At first, the benchmarking data didn't look super remarkable to me but it turns there are many impressive aspects: - Fully open source, open weights + massive ESM Atlas (1.1B structures vs 0.2B for AF3). - SOTA
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Cached at: 05/30/26, 08:10 AM

Took me a while to figure out what all the ESMFold2 rage was about. At first, the benchmarking data didn’t look super remarkable to me but it turns there are many impressive aspects:

  • Fully open source, open weights + massive ESM Atlas (1.1B structures vs 0.2B for AF3).
  • SOTA

Alex Rives (@alexrives): Today we’re announcing ESMFold2, an open scientific engine to power prediction, design, and discovery across protein biology.

The new model delivers state of the art performance on protein interactions, especially antibodies, a critical modality for therapeutics.

We have

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