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Ariadne is a decoder-only route generator for retrosynthetic planning that frames the target, optional constraints, and route as a prompt-completion sequence, achieving superior performance with much less computation compared to traditional search-based planners.
OpenAI and Molecule.one collaborated to have their AI systems (GPT-5.4 and Maria) autonomously select research areas, generate proposals, and run experiments in organic chemistry, achieving yield improvements for 88% of tested reactions — a first for AI-driven open-ended scientific discovery.