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A joint investigation by Science and Retraction Watch has revealed an unreported death case in China involving gene editing therapy: A 6-year-old girl died after receiving a base editing therapy that was not approved by the National Medical Products Administration, raising ethical and regulatory concerns.
Researchers used base editing, a precise genome editing technique, to study the role of the NANOG gene in human embryo development, revealing it is critical for forming pluripotent epiblast cells.