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GPT-5.4, in collaboration with Molecule.one's Maria AI platform, autonomously drove a medicinal chemistry project from literature review to validated experimental result, proposing an unexpected improvement to a widely used reaction in drug discovery.
OpenAI connected GPT-5.4 to an autonomous chemistry AI (Maria) to improve Chan-Lam coupling of primary sulfonamides, achieving significant yield improvements in medicinal chemistry reactions.
OpenAI introduces an updated GPT-Rosalind model purpose-built for life sciences research, with improved performance in medicinal chemistry, genomics, and drug-discovery workflows, and new benchmarks like LifeSciBench and MedChemBench.