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OpenAI and Molecule.one collaborated to have their AI systems (GPT-5.4 and Maria) autonomously select research areas, generate proposals, and run experiments in organic chemistry, achieving yield improvements for 88% of tested reactions — a first for AI-driven open-ended scientific discovery.
GPT-5.4, in collaboration with Molecule.one's Maria AI platform, autonomously drove a medicinal chemistry project from literature review to validated experimental result, proposing an unexpected improvement to a widely used reaction in drug discovery.