longevity

A prediction that by 2035 a major employer will offer a real longevity treatment with a retention clause, adding ten healthy years in exchange for ten more years of loyalty.

In a new interview, Dr. Derya Unutmaz predicts that longevity escape velocity will arrive within 8–10 years, potentially extending lifespan by 50 years, and that cancer will be 100% curable in less than a decade.

Researchers quantitatively assessed for the first time that somatic mutations alone cap human lifespan at 146–194 years, with brain and heart cells as the main bottleneck, while the liver could last millennia.

Garry Tan and Kepano discuss how Markdown files are a durable, universal format that outlasts rapidly evolving apps and intelligence stacks, advocating for investing in formats over apps.

A Verge column discusses the reactions to biohacker Bryan Johnson's autoimmune disease diagnosis, examining the lack of empathy and schadenfreude from wellness influencers.

WIRED hosts a special screening of the documentary 'The Oldest Person in the World' at Green-Wood Cemetery, followed by a discussion on longevity.

British startup Mass Balance launched a self-contained autonomous laboratory into orbit to study disease-causing disordered proteins under microgravity, aiming to generate data to train AI models for drug discovery. The test mission will validate the system's ability to run chemical experiments in space.

This article explains hazard ratios in health studies, why they cannot be directly converted to life expectancy changes without considering risk distribution over time, and clarifies the difference between hazard ratios and relative risks.

A new study suggests that multilingual experience is linked to delayed aging, offering potential cognitive benefits.

Discusses the psychological barrier to viewing aging as a solvable problem rather than a natural inevitability, referencing Aubrey de Grey's concept of the 'pro-aging trance'.

A New Yorker review of Saul Justin Newman's book 'Morbid' argues that many claims of extreme longevity are due to poor record-keeping and age fraud, challenging the foundations of longevity science.

A subscriber-only roundtable discussion hosted by MIT Technology Review explores the frontier of longevity research, focusing on cellular reprogramming as a potential treatment to reverse aging.

A health tracking service that reads signals like longevity, heart rate, sleep, and recovery against user baseline is now open to all, with auditable reasoning steps on Hugging Face and privacy protection via OpenMed_AI PII models.

A biotech company has dosed its first volunteer in a clinical trial for an experimental glaucoma treatment that uses cellular reprogramming to reverse age-related damage, part of a broader trend toward rejuvenation therapies.

Ray Kurzweil predicts that AGI will be achieved by 2029, human lifespan will significantly extend after 2032, AI will eventually merge with the human body, and he emphasizes the importance of thinking in terms of exponential growth.

Article explains how JPL engineers keep the Curiosity rover operating on Mars after 13 years through clever software updates and ongoing maintenance, despite harsh conditions and aging hardware.

The inaugural Enhanced Games in Las Vegas allowed athletes to use performance-enhancing drugs, sparking debate about doping, human enhancement, and longevity culture.

First person treated in a gene therapy trial using partial reprogramming to rejuvenate cells, aiming to treat glaucoma by regenerating optic nerve neurons.

Life Biosciences has dosed its first patient with ER-100, a cellular rejuvenation therapy aiming to reverse age-related sight loss, in a first-ever human clinical trial approved by the FDA.

This newsletter covers David Sinclair's plan to test whole-body rejuvenation drugs in the XPrize competition, key AI trends from a talk at SXSW London, and OpenAI's confidential IPO filing.